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Open Access Article

International Journal of Materials Science. 2022; 4: (1) ; 18-22 ; DOI: 10.12208/j. ijms.20220005.

Preparation and slow release of nanoparticles based on PGA/curcumin
基于PGA/姜黄素纳米颗粒的制备及缓释

作者: 周观淘*, 于雪寅, 余作龙

浙江树人学院 浙江杭州

*通讯作者: 周观淘,单位:浙江树人学院 浙江杭州;

发布时间: 2022-08-05 总浏览量: 27

摘要

以γ-聚谷氨酸(PGA)和壳聚糖(CS)作为基材,聚乙烯吡咯烷酮(PVP)、三聚磷酸钠(STPP)作为稳定剂和交联剂制备缓释姜黄素的纳米颗粒。通过比较不同浓度比配方下的姜黄素在纳米颗粒中的包埋率、结构表征及红外光谱分析确定最优配方;采用动态透析法考察包埋姜黄素的纳米颗粒在2种pH值中的体外释放特性。结果表明得到姜黄素纳米颗粒最优配方:姜黄素浓度0.26mg/mL、PGA浓度0.2%、STPP浓度0.2%、PVP浓度0.1%、CS浓度0.02%(以100mL水溶液计);纳米颗粒平均粒径为526.3nm,分散系数为0.288;制得的纳米粒对姜黄素具有良好的缓释作用。

关键词: 姜黄素;γ-聚谷氨酸;纳米颗粒;制备;缓释

Abstract

Nanoparticles were prepared using γ-polyglutamic acid(PGA), curcumin, and chitosan(CS) as matrix, polyvinylpyrrolidone(PVP) and sodium tripolyphosphate(STPP) as stabilizers and cross-linking agents. The optimal formula was determined by comparing the encapsulation rate, structural characterization and infrared spec- troscopy of curcumin in nanoparticles with different concentration ratio formulations; the in vitro release of nano- particles containing curcumin in two media were investigated by dynamic dialysis. The optimum formula for the production of curcumin nanoparticles were obtained as follows: curcumin concentration was 0.26mg/mL, PGA concentration was 0.2%, STPP concentration was 0.2%, PVP concentration was 0.1% and CS concentration was 0.02%(in 100mL aqueous solution). The average particle size of the nanoparticles was 526.3nm and the dispersion coefficient was 0.288. The prepared nanoparticles had a good slow release effect on curcumin.

Key words: Curcumin; γ-polyglutamic acid; Nanoparticles; Preparation; Slow release

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引用本文

周观淘, 于雪寅, 余作龙 基于PGA/姜黄素纳米颗粒的制备及缓释[J]. 国际材料科学通报, 2022; 4: (1) : 18-22.